What Adverse Event Reports Can and Cannot Tell You
FAERS and the Yellow Card scheme count reports, not cases, and a count with no denominator is not a rate. Here is what a spontaneous report can establish, and what it cannot.
3 articles
Adverse effects as the trials recorded them, plus the risks that only appear outside a trial.
FAERS and the Yellow Card scheme count reports, not cases, and a count with no denominator is not a rate. Here is what a spontaneous report can establish, and what it cannot.
Nausea, vomiting and diarrhoea on semaglutide, tirzepatide and liraglutide cluster during dose escalation and then fade. The rare, serious signals follow a different curve and rest on very different evidence.
GLP-1 receptor agonists keep food in the stomach longer, so a patient who fasted exactly as instructed can still reach induction with a full stomach. Here is what the evidence behind the guidance actually shows.